Your health professional must know about your medical history and ascertain whether you are allergic to any given substance, especially to local anaesthetic (lidocaine) although generally this is quite rare.

Prolotherapy can be safely carried out on diabetics and people suffering from hypertension.

Painful reaction may occur in some individuals; however, these will last only for a very short period (4/5 days).

Should the condition be very painful, paracetamol can be taken and hot packs applied.